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Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications used historically to treat type 2 diabetes and, more recently, to manage weight loss. Already produced in the body, GLP-1 is a hormone secreted in your small intestine that helps regulate blood sugar, control appetite and aid in healthy digestion.
GLP-1 agonists work by mimicking the naturally occuring GLP-1 by increasing the release of insulin — the hormone that controls blood glucose by moving it into cells — and suppressing the release of glucagon, which releases glucose from the liver into the blood.
The medication works in three main ways for weight loss: metabolic optimization by controlling blood sugar, reducing food noise by acting on the GLP1 receptors in the brain, and by delaying gastric emptying therefore keeping you fuller, longer.
Semaglutide is a GLP-1 receptor agonist that mimics the GLP-1 hormone to help regulate appetite and blood sugar.
In a the STEP 1 study released in 2021, it was found that participants with overweight or obesity, on 2.5 mg of semaglutide once weekly who added lifestyle intervention showed clinically relevant reduction in body weight. Their mean loss was 15% and within our practice, on the program led by Dr. Blum, patients see an average loss of well into the 20 percentile.
Read more about the study here.
Tirzepatide is a dual agonist that targets both GLP-1 and GIP (Glucose-dependent Insulinotropic Polypeptide) receptors, which can lead to more significant improvements in blood sugar control and weight loss.
In a study released in 2022, it was found that once weekly tirzepatide resulted in a 15% loss in weight on a dose of 5 mg, 19.5% loss at a dose of 10 mg and 20.9% loss at a dose of 15 mg.
Read more about the study here.
Before your consultation, you'll need to provide recent bloodwork from the last 12 months. Blood work must include: a complete blood count, lipids panel, A1C, TSH/ T4 and comprehensive metabolic panel.
If you do not already have recent bloodwork, you can book Weight Wellness Blood Work Labs with us.
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We believe in holistic wellness, which means we treat both the symptoms of weight loss - and the root cause. We can't wait to learn more about you!
