Microdosing a GLP-1 (glucagon-like peptide-1) receptor agonist involves taking very small, subtherapeutic doses of the medication, which is typically used in higher doses to help people lose weight or to manage conditions like type 2 diabetes or obesity. Knowing the benefits that microdosing can have, we have been thrilled to work on and introduce a microdosing specific program. This program functions similar to our standard weight wellness program with unlimited access to our medical team and with guidance about lifestyle tweaks to make to live your best, most healthy life. The microdosing program is $299 every five weeks and is specifically for doses under .2 mg. The subscription fee includes all medication and care. You can book an appointment to kick off the microdosing program with code MICRODOSE to get your first appointment and first five weeks of dosing/ medication for $299.
The idea behind microdosing is to leverage the benefits of GLP-1s without the full range of effects seen at therapeutic doses. Those benefits include:
GLP-1 medications reduce inflammation through multiple mechanisms, including modulation of immune cells, reduction of pro-inflammatory cytokines, improvement in adipose tissue function, and protection against vascular and neuroinflammation. Chronic or excessive inflammation can contribute to a range of symptoms – bloating, joint pain, muscle stiffness, headache, fatigue, sleep issues, skin issues, immune response – the list goes on. When inflammation is reduced, many people report a noticeable improvement in various physical and mental aspects of their well-being. Most people who microdose GLP-1s specifically for inflammation see increased energy and mental clarity, report feeling less pain and stiffness and even share that their general mood improves. Reducing chronic inflammation is considered an important strategy for longer, happier lives – especially in the context of metabolic, autoimmune, and cardiovascular diseases.
GLP-1 receptor agonists (such as semaglutide or tirzepatide) help to reduce appetite by promoting feelings of fullness and delaying gastric emptying. Microdosing might provide subtle effects on appetites without the risk of side effects like nausea that can sometimes occur at higher doses. The effect can look like less cravings throughout the day, healthier choices, less desire to drink alcohol and help with any tendencies to emotionally eat when you’re not hungry. Microdoses typically work “behind the scenes,” but can do a great job at maintaining your weight depending on your internal root causes of weight.
GLP-1 agonists help to improve insulin sensitivity and reduce blood sugar levels by stimulating insulin secretion in a glucose-dependent manner. At microdoses, these benefits could support metabolic health, potentially aiding in the management of insulin resistance or prediabetes, even in the absence of overt diabetes. As you age, it’s more common and likely to experience some insulin resistance.
There is growing evidence that GLP-1 receptors play a role in brain function, including regulating mood and possibly protecting against neurodegenerative diseases like Alzheimer’s and Parkinson's – as noted here in multiple ongoing studies. Microdosing could have subtle cognitive or mood-enhancing effects.
GLP-1 receptor agonists have been shown to provide cardiovascular benefits, such as reducing blood pressure, improving cholesterol profiles, and decreasing the risk of heart disease. With permission from the patient, we have an early 40s marathon runner who has been seeing significant improvement in their own cholesterol and lipids since starting their microdosing journey.
With everything in the news about GLP-1 side effects, it’s totally normal to be nervous about starting a GLP-1 journey. A significant benefit of microdosing is the reduction of common side effects associated with GLP-1 agonists, such as nausea or gastrointestinal discomfort and then having the ability to slowly increase without side effect if you need a higher dose – whether it’s still at a microdosing level or if temporarily at a more therapeutic level. Lower doses can even provide the desired effects on glucose regulation or appetite without triggering these adverse reactions.
If microdosing promotes gradual weight loss, improved insulin sensitivity, and cardiovascular health over time, it could offer a safer, long-term strategy for improving metabolic health with fewer disruptions to daily life compared to extreme dieting, cortisol raising workouts, or lifestyle interventions that can have the opposite of the desired effect.
Our microdosing specific program has been functioning behind the scenes for a few months and we've been thrilled to see similar success metrics come to fruition for the patients who have been on microdoses. If you're ready to start microdosing a GLP-1, you can book an appointment to kick off the microdosing program with code MICRODOSE to get your first appointment and first five weeks of dosing/ medication for $299 or you can send us an email at info@theaestheticconcierge.co to see if microdosing might be right for you!
With patients in North Carolina, South Carolina, Alabama, Texas, Arizona, New York and more already finding success on a GLP-1, we cannot wait to meet and work with you!
